Jonny Evans was handed his first start for Manchester United in eight years after returning to the club, while Sofyan Amrabat could make his debut after being named on the bench.
Man Utd starting XI: Onana, Dalot, Lindelof, Evans, Reguilon, Casemiro, McTominay, Hannibal, Fernandes, Hojlund, Rashford
Burnley starting XI: Trafford, Roberts, Al Dakhil, Beyer, Taylor, Cullen, Brownhill, Ramsey, Gudmundsson, Koleosho, Amdouni